The group of Annona spp., including A. squamosa, A. muricata, and A. cherimola contain acetogenin alkaloid compounds that are said to have anticancer properties.

One such alkaloid, bulatacin, was shown to possess antitumor potential against cancerous liver tumors (Chih et al., 2003). Annona muricata leaves are said to destroy colon cancer cells (Moghadamtousi et al., 2014). Acetogenins were also reported to destroy human hepatoma cell lines (Liaw et al., 2002).

The fruit is said to contain small amounts of neurotoxic alkaloids, and consuming large quantities of the fruit could cause Parkinson-like symptoms (Memorial Sloan-Kettering Cancer Center, 2011; Champy et al., 2005).

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