Sudhir Ahluwalia
Piperine found in pepper gives the peppery taste in our mouth. Its role in vascular systems has been studied. Many of us look towards scientific evidence to ancient medicinal use of common herbs and spices. The article by Atanasov AG et al gives us a peak into the science behind ancient medicine.
Planta Med. 2015 Aug;81(12-13):1065-74. doi: 10.1055/s-0035-1546165. Epub 2015 Jul 1.

Piperine Congeners as Inhibitors of Vascular Smooth Muscle Cell Proliferation.

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 Abstract

Successful vascular healing after percutaneous coronary interventions is related to the inhibition of abnormal vascular smooth muscle cell proliferation and efficient re-endothelialization. In the search for vascular smooth muscle cell anti-proliferative agents from natural sources we identified piperine (1), the main pungent constituent of the fruits from Piper nigrum (black pepper). Piperine inhibited vascular smooth muscle cell proliferation with an IC50 of 21.6 µM, as quantified by a resazurin conversion assay. Investigations of ten piperamides isolated from black pepper fruits and 15 synthesized piperine derivatives resulted in the identification of three potent vascular smooth muscle cell proliferation inhibitors: the natural alkaloid pipertipine (4), and the two synthetic derivatives (2E,4E)-N,N-dibutyl-5-(3,5-dimethoxyphenyl)penta-2,4-dienamide (14) and (E)-N,N-dibutyl-3-(naphtho[2,3-d][1,3]dioxol-5-yl)acrylamide (20). They showed IC50 values of 3.38, 6.00, and 7.85 µM, respectively. Furthermore, the synthetic compound (2E,4E)-5-(4-fluorophenyl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (12) was found to be cell type selective, by inhibiting vascular smooth muscle cell proliferation with an IC50 of 11.8 µM without influencing the growth of human endothelial cells.

Georg Thieme Verlag KG Stuttgart · New York.

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